In the aftermath of a heartbreaking tragedy, a scholar and writer uses Dante's Divine Comedy to shepherd him through the dark wood of grief and mourning--a rich and emotionally resonant memoir of suffering, hope, love, and the power of literature to inspire and heal the most devastating loss.Where do we turn when we lose everything? Joseph Luzzi found the answer in the opening of The Divine Comedy: "In the middle of our life's journey, I found myself in a dark wood."When Luzzi's pregnant wife was in a car accident--and died forty-five minutes after giving birth to their daughter Isabel--he found himself a widower and first-time father at the same moment. While he grieved and cared for his infant daughter, miraculously delivered by caesarean before his wife passed, he turned to Dante's Divine Comedy for solace.In a Dark Wood tells the story of how Dante helped the author rebuild his life. He follows the structure of The Divine Comedy, recounting the inferno of his grief, the purgatory of healing and raising Isabel on his own, and then paradise of the rediscovery of love.A Dante scholar, Luzzi has devoted his life to teaching and writing about the poet. But until he turned to the epic poem to learn how to resurrect his life, he didn't realize how much the poet has given back to him. A meditation on the influence of great art and its power to give us strength in our darkest moments, In a Dark Wood opens the door into the mysteries of Dante's epic poem. Beautifully written and flawlessly balanced, Luzzi's book is a hybrid of heart-rending memoir and critical insight into one of the greatest pieces of literature in all of history. In a Dark Wood draws us into man's descent into hell and back: it is Dante's journey, Joseph Luzzi's, and our very own.

Product Description: FOR USE IN SCHOOLS AND LIBRARIES ONLY. Serafina has never had a reason to disobey her pa and venture beyond the grounds of the Biltmore estate.There's plenty to explore in her grand home, although she must take care to never be seen...read more

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Product Description: Born blind and hairless, baby squirrels must rely on momma in their first stage of life. Give them 7-10 weeks, and these babies will be able to venture on their own. Climb along in this beginner book for young readers.

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Product Description: A New York Times Bestselling Author A USA Today Bestselling Author A Stardust, Texas Novel A year after being dumped at the altar and two days after turning the big 3-0, Jodi decides to break some rules. She crashes a swanky wedding and has a fling with the Dallas Gunslingers' star hitter...read more

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Product Description: Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed...read more

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Product Description: The last 15 years have brought an understanding of growth and differentiation at the molecular level, expanding our knowledge of the origin and progression of cancer. Early breakthroughs defining growth control pathways came via studies of oncogenes, mutated signaling molecules that have lost the capacity to tum off their proliferative signal...read more

Antifolates are an important class of anticancer drugs originally developed as anti leu kemic agents, but now used, usually in combination with other drugs, for the treatment of a wide range of tumors, notably carcinomas of the head and neck, breast, germ cell tumors, non-Hodgkin's lymphoma, acute lymphoblastic leukemia, and osteogenic sar comas. 5-Fluorouracil and its prodrugs also target, in part, the folate-dependent enzyme, thymidylate synthase. Furthermore, folate supplementation in the form of leucovorin, modulates 5-fluororuacil activity. 5-Fluorouracil is widely used in the treatment of colorectal and gastric cancer and in combination for other solid tumors such as breast and head and neck cancers. Ongoing clinical trials with the newer antifolates suggest that the range of solid tumors where these agents will be of use may broaden further. Half a century ago, interesting scientific and clinical discoveries suggested that folie acid was a vitamin involved in vital cellular metabolic processes. The folate analogs, aminopterin and methotrexate, were synthesized by the American Cyanamid Company in an attempt to interfere with these processes and were shown to have anticancer activity by Farber and his colleagues. Hence, the principle of antimetabolite therapy for the treatment of cancer was established. Biomedical research over the following years led to a deeper understanding of the complex biochemical pharmacology of folates and antifolates. Selective antimicrobial agents were discovered, but more tumor-selective anticancer agents did not immediately emerge.

Product Description: We are in an exciting era in the war against cancer, with real prospects for novel anticancer drugs that are cancer cell-specific without the toxicities that have been the hallmark of conventional cytotoxic cancer chemotherapy. Advances in cancer cell biology fueled by the molecular biology revolution have resulted in the uncovering of many novel potential molecular targets for cancer therapy...read more