This title presents a comprehensive overview of the principles, methods and fundamental theories used in the separation, quantification and analysis of individual compounds and substances. It identifies recent advances, mathematical relationships and useful design techniques for optimal system operation and control of chemical and chromatographic processes.

Chiral Chromatography Thomas E. Beesley Advanced Separation Technologies Inc., Whippany, New Jersey, USA Raymond P. W. Scott Chemistry Department, Georgetown University, Washington DC, USA and Chemistry Department, Birkbeck College, University of London, UK Analytical techniques based on separation processes, such as chromatography and electrophoresis, are finding a growing range of applications in chemical, pharmaceutical and clinical laboratories. The Wiley Separation Science Series provides the analyst in these laboratories with well-focused books covering individual techniques, so that they can be applied more efficiently and effectively to contemporary analytical problems. The different enantiomers of a drug can exhibit widely different physiological activity in degree and nature. As a result, the separation and identification of enantiomers is now a very important analytical problem and chiral chromatography is the natural technique to apply to the resolution of such mixtures. Chiral Chromatography provides the reader with a basic understanding of the nature of chromatographic separations and relates the principles specifically to the separation of enantiomers. The following information is included: * chiral separations involving both gas and liquid chromatography * descriptions of the apparatus used for both techniques * detailed discussion on the retention mechanism that results in chiral selectivity * the structure and synthesis of a wide range of chirally active stationary phases used in both gas and liquid chromatography * preparative applications for large scale purification of enantiomers * applications of capillary electrophoresis and capillary electrochromatography. In addition to the above, a large number of examples of the separation of both commercially and physiologically interesting chiral mixtures are given, as is a detailed discussion on the mechanism of selectivity of each example. Thomas Beesley was founder and is the CEO for a leading manufacturer of chiral stationary phases and has published papers on TLC, HPLC and chiral separations involving cyclodextrins. He has also coauthored papers with Daniel W. Armstrong, an expert on modern cyclodextrin columns. Raymond Scott has worked in the field of separation science for over 40 years and has contributed extensively to the development of both gas and liquid chromatography publishing over 160 papers on the subjects.

A comprehensive manual for the analyst (or chromatographer) for evaluating and using the various tandem systems obtained by combining different methods of chromatography and spectroscopy. It introduces the reader to the different separation techniques that can be combined with spectroscopic techniques. Gives essential details of the different interface designs that are necessary for each tandem technique. Provides practical examples of the use of each technique, describing the analytical performance and sensitivity in terms that allow direct comparison between techniques. In addition to describing research prototype tandem combinations, it presents commercially available systems. Offers many detailed diagrams to facilitate rapid comprehension.

Product Description: Highlights critical factors involved in successful chromatographic analysis. Details analytical procedures; outlining sample preparation, collection, transportation, and storage. Provides step-by-step guidelines for producing analytical reports.

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"Comprehensively covers the design, construction, and operation of gas chromatography, liquid chromatography, and thin-layer chromatography detectors--all in one convenient, up-to-date source. Emphasizes the essential use of common specifications to describe all detectors, allowing easy comparison of their attributes."

Product Description: This work introduces scientists of all disciplines to the chromatographic process and how it functions. The basic principles of chromatographic separation and specific chromatographic procedures, including gas, liquid and thin-layer chromatography, are covered...read more

This work provides a clear presentation of the chromatographic process - demonstrating the functions of all associated instrumentation and the procedures necessary to obtain accurate qualitative and quantitative results. The work supplies a host of applications from a variety of sources to help identify the best equipment, the most appropriate columns and the most suitable phase systems for specific samples.

Product Description: Deals with silica gel from the perspective of both the analytical chemist and chromatographer. Provides the reader with a basic understanding of the physical and chemical properties of silica gel and bonded phases as well as how these properties impact on the quality of the separations that are achieved by them...read more (view table of contents, read Amazon.com's description)

Product Description: Liquid Chromatography Column Theory Raymond P.W. Scott, Chemistry Department, Birkbeck College, University of London, UK and Chemistry Department, Georgetown University, Washington DC, USA Analytical techniques based on separation processes, such as chromatography and electrophoresis, are finding a growing range of applications in chemical, biochemical and clinical laboratories...read more (view table of contents, read Amazon.com's description)