Product Description: This volume addresses current emerging concepts in the field of angiogenesis, including important angiogenesis modifiers which are essential in combination with growth factors (VEGF and FGF) for the physiological process and also for therapeutic applications...read more

Product Description: Advances in genetics, molecular biology and gene delivery technologies in recent years have led to new gene therapy strategies for treatment of a variety of diseases. This book gives a comprehensive overview of the present status and future directions of gene delivery systems and therapeutic strategies for the clinical application of gene therapy in cancer, cardiovascular and central nervous system diseases...read more

Product Description: Vascular Protection explores advances in vascular biology and how they translate into innovations in drug therapy for vascular disease. It addresses recent advances in the knowledge of endothelial vasoactive factors and other biologically active molecules as well as gene therapy...read more (view table of contents, read Amazon.com's description)

The cardiovascular system is the first functional organ system to develop in the vertebrate embryo. Embryonic growth and differentiation essentially depend on transport of nutrients and waste through the early vasculature, and certain events in morphogenesis are thought to be influenced by the hemodynamic forces of the beating heart. The vasculature not only serves as a 'nutrient and waste pipeline' but is also a major communication system between distant organs and tissues. The vascular endothelial cell mediates vascular growth, permeability, integrity and interactions with blood cells. In most tissues the endothelium itself is highly specialized to meet the particular needs of the tissue in terms of quality and quantity of incoming and outgoing molecules and messages.The areas covered by Morphogenesis of the Endothelium include the formation of blood vessels in embryonic tissues by vasculogenesis and angiogenesis and the differentiation of endothelium in organs. The contributors are leaders in the field of cardiovascular development, biology and pathology and have written up to date chapters on the mechanisms of blood vessel formation and function in embryos and the adult.

Product Description: Outlines strategies for stimulating capillary formation in hypoxia and ischemia and inhibiting it in cancer, diabetes, and chronic inflammation.This state-of-the-science reference highlights recent progress in the ways to promote formation of new blood vessels in ischemic/hypoxic tissue and the means to stifle capillary growth and development in solid tumors, diabetic retinopathy, and chronic immuno/inflammatory disorders such as rheumatoid arthritis and psoriasis...read more (view table of contents, read Amazon.com's description)

Product Description: Over the past decade, rapid progress had been made in elucidating the cellular and molecular mechanisms of new blood vessel formation in both health and disease. Lack of sufficient angiogenesis (new capillary development) and collateral formation (remodeling of existing blood vessels) in adult tissues (e...read more

Product Description: Research on the key mediator nitric oxide has increased exponentially over the last ten years. It is now clear that, in addition to its role within the cardiovascular system, this mediator is also implicated in the normal physiological function and disease pathology of several organs and systems...read more (view table of contents, read Amazon.com's description)

Product Description: Estrogen and the Vessel Wall marks the start of a new era in understanding the cardiovascular actions of estrogen. It examines the hypothesis, derived from a growing body of epidemiological data, that estrogen acts directly upon the vessel wall to produce beneficial effects in the cardiovascular system...read more (view table of contents, read Amazon.com's description)

Product Description: Highlighting the transition from basic research to clinical applications, this unique reference presents the endothelium as both the source and the target of novel therapeutic concepts and discusses the involvement of the endothelium in mainstream approaches to the treatment of various conditions...read more

Product Description: With contributions from leading experts, this book provides an in-depth review of the state-of-the-art of current knowledge on the biophysical principles of mechanoreception, and the phenomenon of myogenic tone and autoregulation...read more

Product Description: This book endeavours to present an overview of the most important developments in prostacyclin research over recent years. The first part of the book deals with the three most relevant new areas of prostacyclin research: 1) analysis of novel mechanism(s) of action in "traditional" target cells (vascular smooth muscle and platelets); 2) study of the effect of prostacyclin on novel targets (e...read more

Product Description: "This unique monograph provides an in-depth account of the interactions between endothelial cells and their products with vascular smooth muscle -- highlighting how endothelial-derived products influence vascular tone and regulation of blood flow, including platelet aggregation...read more

Product Description: Merely three years after the discovery of endothelin, a large amount of information has been generated about the molecular biology, biosynthesis, biological actions and potential physiological and pathological importance of this unique peptide and its isoforms...read more

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Product Description: Book by Rubanyi, Gabor M.