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Theory and Practice in Complex Dose-finding Designs
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Bibliographic Detail
Publisher Springer Verlag
Publication date May 13, 2017
Pages 100
Binding Paperback
Book category Adult Non-Fiction
ISBN-13 9784431555728
ISBN-10 4431555722
Dimensions 0 by 6.10 by 9.25 in.
Original list price $69.99
Summaries and Reviews description: Product Description: This book deals with advanced methods for adaptive phase I dose-finding clinical trials for combination of two agents and molecularly targeted agents (MTAs) in oncology. It provides not only methodological aspects of the dose-finding methods, but also software implementations and practical considerations in applying these complex methods to real cancer clinical trials. Thus, the book aims to furnish researchers in biostatistics and statistical science with a good summary of recent developments of adaptive dose-finding methods as well as providing practitioners in biostatistics and clinical investigators with advanced materials for designing, conducting, monitoring, and analyzing adaptive dose-finding trials. The topics in the book are mainly related to cancer clinical trials, but many of those topics are potentially applicable or can be extended to trials for other diseases. The focus is mainly on model-based dose-finding methods for two kinds of phase I trials. One is clinical trials with combinations of two agents. Development of dose-finding methods for two-agent combination trials requires reasonable models that can adequately capture joint toxicity probabilities for two agents, taking into consideration possible interactions of the two agents on toxicity probability such as synergistic or antagonistic effects. Another is clinical trials for evaluating both efficacy and toxicity outcomes in single- and two-agent combination trials. These methods are often applied to the phase I trials including MTAs because the toxicity and efficacy for a MTA does not monotonically increase with dose, but the efficacy often increases initially with the dose and then plateaus. Successful software implementations for several dose-finding methods are introduced in the book, and their operating characteristics in practice are discussed. Recent advance of the adaptive dose-finding methods in drug developments are also provided.

Book cover for 9780448027890 Book cover for 9784431555728
The price comparison is for this edition
With Hiroyuki Sato, Takashi Daimon, Akihiro Hirakawa | from Springer Verlag (May 13, 2017)
9784431555728 | details & prices | 100 pages | List price $69.99
About: This book deals with advanced methods for adaptive phase I dose-finding clinical trials for combination of two agents and molecularly targeted agents (MTAs) in oncology.
With Hiroyuki Sato, George Ulrich (other contributor), Takashi Daimon, Akihiro Hirakawa | from Grosset & Dunlap (October 1, 1989); titled "Baby's Peek-A-Boo"
9780448027890 | details & prices | 7.00 × 8.25 × 0.75 in. | 0.10 lbs | List price $4.99
This edition also contains Baby''s Peek-A-Boo

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