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Network Medicine: Complex Systems in Human Disease and Therapeutics
By Edwin K. Silverman (editor), Albert-Laszlo Barabasi (editor), Elliott M. Antman (contributor) and Joseph Loscalzo (editor)
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Bibliographic Detail
Publisher Harvard Univ Pr
Publication date February 1, 2017
Pages 500
Binding Hardcover
Book category Adult Non-Fiction
ISBN-13 9780674436534
ISBN-10 0674436539
Dimensions 0 by 6.13 by 9.25 in.
Original list price $45.00
Summaries and Reviews
Amazon.com description: Product Description:

Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in network medicine, this definitive volume provides readers with a state-of-the-art synthesis of the progress being made and the challenges that remain.

Medical researchers have long sought to identify single molecular defects that cause diseases, with the goal of developing silver-bullet therapies to treat them. But this paradigm overlooks the inherent complexity of human diseases and has often led to treatments that are inadequate or fraught with adverse side effects. Rather than trying to force disease pathogenesis into a reductionist model, network medicine embraces the complexity of multiple influences on disease and relies on many different types of networks: from the cellular-molecular level of protein-protein interactions to correlational studies of gene expression in biological samples. The authors offer a systematic approach to understanding complex diseases while explaining network medicine’s unique features, including the application of modern genomics technologies, biostatistics and bioinformatics, and dynamic systems analysis of complex molecular networks in an integrative context.

By developing techniques and technologies that comprehensively assess genetic variation, cellular metabolism, and protein function, network medicine is opening up new vistas for uncovering causes and identifying cures of disease.



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Hardcover
Book cover for 9780674436534
 
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With Edwin K. Silverman (other contributor), Albert-Laszlo Barabasi (other contributor), Joseph Loscalzo (other contributor) | from Harvard Univ Pr (February 1, 2017)
9780674436534 | details & prices | 500 pages | List price $45.00
About: Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before.

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