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Tables of Contents for Leukemia
Chapter/Section Title
Page #
Page Count
List of Contributors
ix
2
Preface to the Third Edition
xi
1
Preface to the First Edition
xii
1 Epidemiology
1
30
R.A. CARTWRIGHT
Introduction
1
1
Descriptive epidemiology
2
9
Clusters
11
1
Aetiological factors
12
9
Conclusion
21
10
2 Morphology and Classification of Leukaemias
31
21
B.J. BAIN
Introduction
31
1
Myeloid leukaemias and macrophage neoplasms
31
10
Lymphoid leukaemias and lymphomas
41
1
B-lineage chronic lymphoid leukaemias
42
3
T-lineage chronic lymphoid leukaemias
45
2
Plasma cell dyscrasias
47
2
Biphenotypic leukaemias
49
3
3 Cytogenetics
52
19
P.W. THOMPSON
Introduction
52
1
Chronic myeloid leukaemia
53
1
Myeloproliferative disorders
54
1
Acute myeloid leukaemia
55
2
Myelodysplastic syndrome
57
1
Secondary myelodysplastic syndrome/acute myeloid leukaemia
58
1
Acute lymphoblastic leukaemia
58
3
Chronic lymphoproliferative disorders
61
1
Lymphoma
62
1
Bone marrow transplantation
62
1
Fluorescence in situ hybridization
63
8
4 Immunophenotyping
71
16
D. CAMPANA
F.G. BEHM
Introduction
71
1
Normal lymphohaemopoietic differentiation
71
2
Classification of acute leukaemia
73
3
Relation of cell markers to treatment outcome
76
1
Phenotype of lymphoproliferative disorders
77
1
Detection of minimal residual disease in acute leukaemia
78
9
5 Acute Lymphoblastic Leukaemias
87
18
C.C. BAILEY
S.E. KINSEY
Clinical features and diagnosis
87
1
Essential investigations
87
3
Indicators of prognosis
90
1
Indicators of prognosis-laboratory features
91
2
Treatment
93
4
Relapse
97
2
Bone marrow transplantation
99
1
Supportive care
99
1
Late effects of treatment
100
1
Conclusion
101
4
6 Chronic Lymphocytic Leukaemias
105
31
T.J. HAMBLIN
D.G. OSCIER
History
105
1
Epidemiology
105
1
Aetiology
106
1
Clinical features
106
1
Laboratory findings
107
3
Nature of the leukaemic cell
110
4
Differential diagnosis
114
1
Natural history, staging and prognosis
115
2
Complications
117
1
Management
118
5
Prolymphocytic leukaemia
123
1
Splenic lymphoma with villous lymphocytes
123
1
Large granular lymphocytosis
124
12
7 Adult T-cell Leukaemia/Lymphoma
136
15
E. MATUTES
D. CATOVSKY
Introduction
136
1
Clinical features
136
1
Laboratory investigations
137
3
Histology of affected tissues
140
1
Detection of HTLV-I
141
4
Chromosome abnormalities
145
1
Diagnostic criteria and differential diagnosis
145
1
Prognosis and treatment
145
6
8 Hairy Cell Leukaemia
151
14
J. BURTHEM
J.C. CAWLEY
Introduction
151
1
Clinical and laboratory aspects
151
2
Pathology
153
1
Diagnosis
154
1
Treatment
154
3
Biology of the malignant cell
157
8
9 Acute Myeloid Leukaemia: Clinical Features and Management
165
21
J.A. WHITTAKER
Clinical features
165
2
Blood in acute myeloid leukaemia
167
1
Special clinical problems
168
3
Prognostis factors
171
1
Treatment
172
3
Special problems of treatment
175
11
10 Acute Myeloid Leukaemia: Recent Clinical Trial Data and Future Prospects
186
9
L.G. ROBINSON
A.K. BURNETT
Introduction
186
1
Haemopoietic growth factors
186
2
Anthracyclines in treatment
188
1
Autologous bone marrow transplantation
189
2
Cytosine arabinoside treatment
191
1
Future clinical trials
192
3
11 Myelodysplasia and Preleukaemia
195
34
C.G. GEARY
A.T. MACHETA
Introduction
195
1
Incidence
196
1
Pathogenesis of myelodysplasia
196
1
Classification of the myelodysplastic syndrome
197
1
Clinical findings
198
1
Morphological abnormalities
198
3
Specific types of the myelodysplastic syndrome
201
10
Diagnosis
211
1
Cytogenetic abnormalities in primary and secondary myelodysplastic syndrome
212
1
Clinical course and prognosis
213
1
Treatment
214
5
Relationship of myelodysplasia to acute myeloid leukaemia and other clonal marrow disorders
219
10
12 Secondary Leukaemias
229
23
D.A. WINFIELD
J.S. LILLEYMAN
Introduction
229
1
Leukaemias induced by cytotoxic drugs
229
2
Diseases associated with secondary leukaemia
231
7
Leukaemias induced by noncytotoxic drugs
238
1
Leukaemia following exposure to chemical myelotoxins
238
2
Leukaemia following exposure to ionizing radiation
240
2
Leukaemia following exposure to nonionizing radiation (electromagnetic fields)
242
1
Diseases predisposing to leukaemia
243
9
13 Chronic Myeloid Leukaemia
252
18
J.M. GOLDMAN
Introduction
252
1
Classification
252
1
Epidemiology, aetiology and natural history
252
1
Cytokinetics
253
1
Cytogenetics
254
1
Molecular biology
254
2
Clinical features
256
1
Haematological and other investigations
257
2
Cytogenetic and molecular studies
259
1
Variants of chronic myeloid leukaemia
260
1
Management
261
9
14 Myeloma
270
23
J.A. CHILD
G.J. MORGAN
Introduction
270
1
Diagnostic features
270
3
Staging and prognostic factors
273
5
Treatment
278
4
Response criteria and definitions
282
4
Future developments
286
7
15 Morphology and Classification of Hodgkin's Disease
293
9
K.A. MacLENNAN
Introduction
293
1
Lymphocyte-predominant Hodgkin's disease
294
1
Nodular sclerosis
295
1
Lymphocyte-depleted Hodgkin's disease
296
1
Mixed cellularity Hodgkin's disease
296
6
16 Hodgkin's Disease: Clinical Features and Management
302
27
P. SELBY
P. JOHNSON
Introduction
302
1
Epidemiology
302
1
Molecular pathology, clonality and cell of origin
303
1
Cell biology
303
1
Clinical presentation
304
1
Imaging investigations
305
2
Staging laparotomy
307
1
Management
307
6
Intensive therapy with haemopoietic support in the treatment of Hodgkin's disease
313
2
Antibody-based therapy
315
1
Special clinical problems
315
1
Side effects of therapy
316
2
Psychosocial consequences of Hodgkin's disease and its treatment
318
1
Causes of death after treatment
319
1
Conclusion
319
10
17 Morphology and Classification of Non-Hodgkin's Lymphoma
329
19
A.J. NORTON
Introduction
329
1
Classification
329
1
Diagnostic methods
330
1
B-cell lymphomas
331
8
T-cell lymphomas and lymphomas of putative NK-cell lineage
339
9
18 Non-Hodgkin's Lymphoma: Low Grade
348
28
S.A.N. JOHNSON
Introduction
348
1
Classification and staging systems
348
1
Low-grade non-Hodgkin's lymphoma B-cell types
349
15
Low-grade non-Hodgkin's lymphoma T-cell types
364
3
Conclusion
367
9
19 Non-Hodgkin's Lymphoma: Histologically Aggressive
376
16
D.C. LINCH
Introduction
376
1
Aetiology
376
1
Classification of histologically aggressive non-Hodgkin's lymphoma
377
2
Chromosomal abnormalities
379
1
Staging
380
1
Risk of central nervous system disease
380
1
Prognostic factors
380
1
Management
381
11
20 The Lymphomas: Current Clinical Trials
392
8
S.J. PROCTOR
P.R.A. TAYLOR
Introduction
392
1
Hodgkin's disease
393
2
Low-grade non-Hodgkin's lymphoma
395
1
High-grade non-Hodgkin's lymphoma
396
1
Extranodal non-Hodgkin's lymphoma
397
1
Conclusion
398
2
21 Allogeneic Bone Marrow Transplantation: Donor Selection
400
18
J.HOWS
B.BRADLEY
Introduction
400
1
Cellular aspects of alloreactivity
401
1
Molecular aspects of alloreactivity
402
3
Theoretical considerations influencing donor selection
405
1
Application of typing and matching techniques
406
2
Functional assays for donor selection
408
1
Finding an `acceptable' donor
409
3
Allogeneic peripheral blood progenitor cell donors
412
1
Umbilical cord blood donations
413
1
Impact of current research on donor selection
414
4
22 Allogeneic Bone Marrow Transplantation: Clinical Management
418
37
I.M. FRANKLIN
Introduction
418
2
Technique for allogeneic bone marrow transplantation
420
12
Graft-vs-host disease
432
4
Bone marrow engraftment
436
1
Indications for and results of allogeneic bone marrow transplantation
437
6
Relapse after allogeneic bone marrow transplantation
443
1
Second malignancies
443
1
Support for patients and staff
444
1
Conclusion
444
11
23 Autologous Blood and Marrow Transplantation
455
27
J. MEHTA
R.L. POWLES
Introduction
455
1
Haematopoietic stem cells
455
2
Conditioning regimens
457
2
Clinical results
459
14
Postautograft strategies to reduce relapse
473
1
Management of advanced disease
474
1
Conclusion
474
8
24 Supportive Care: Blood Products
482
20
J.A.F. NAPIER
Introduction
482
1
Platelet transfusion
482
13
Transfusion of red cells
495
1
Granulocyte therapy
495
1
Cytomegalovirus transmission
496
6
25 Supportive Care: Infection
502
29
J.A. LIU YIN
Introduction
502
1
Infection as a cause of morbidity and mortality in acute leukaemia
502
1
Predisposing factors associated with infection
502
3
Diagnosis of infection
505
1
Colonization and infection
505
1
Bacterial infections
506
1
Fungal infections
506
2
Pneumocystis carnii infections
508
1
Viral infections
508
1
Infection prophylaxis
509
1
Infection prophylaxis and prevention of infection from endogenous flora
510
3
Enhancement of host defences
513
1
Treatment of infection in the neutropenic patient
514
5
Treatment of fungal infections
519
1
Treatment of Pneumocystis carinii pneumonia
520
1
Granulocyte transfusions
520
2
Haemopoietic growth factors
522
9
26 Haemostasis and Thrombosis
531
13
P.H. RODDIE
C.A. LUDLAM
Normal haemostasis
531
3
Haemostatic defects in leukaemia
534
3
Thrombosis
537
7
27 Design of Clinical Trials
544
8
H.S. CUCKLE
Introduction
544
1
Trial design
544
5
Analysis of results
549
1
Interpretation of results
550
1
Conclusion
551
1
28 Gene Transfer in Leukaemia and Related Disorders
552
11
M.K. BRENNER
Introduction
552
1
Gene transfer to haemopoietic stem cells
552
1
Applications of gene transfer to the therapy of haematological malignancy
552
2
Current uses of gene transfer for leukaemia and related disorders
554
5
Safety of gene transfer
559
1
Conclusion
559
4
Index
563
Colour plates appear between pp. 292 and 293