Preface

Contributing Authors

Participants

Part I: Methods in Mass Spectrometry

Electrospray Ionization: Theory and Application

S.J. Gaskell

M.S. Bolgar

I. Riba

S.G. Summerfield

Atmospheric Pressure Ionization (ESI and APCI) Theory and Application

A. Raffaelli

Matrix-Assisted Laser Desorpition-Ionization (MALDI) Mass Spectrometry: Principles and Applications

M. Karas

U. Bahr

High Sensitivity ESI/MS and MALDI MS

T.B. Farmer

R.M. Caprioli

Optimised GC/MS Interfacing Systems and Operating Conditions

P.J. Arpino

Quantitative Analysis by Mass Spectrometry: Some Important Considerations

M.W. Duncan

Optimization of Mass Spectrometric Ionisation Efficiency Data

I.T. Ozgen

O. Altungoz

B. Salih

B.G.M. Vandeginste

Role of Internal Energy in Mass Spectrometric Fragmentation

K. Vekey

Interaction of Metal Ions and Protons with Simple Biomolecules. Structure Information from Bond Energies and Entropy Effects

B.A. Cerda

M.J. Nold

C. Wesdemiotis

A Promising Marriage Between Theory and Experiment: Density Functional Method Versus Mass Spectormtry

T. Marina

N. Russo

E. Sicilia

M. Toscano

Part II: Instrumentation for Mass Analysis and Detection

Recent Advances in Magnet Sector Mass Spectrometry

O.V. Nermirovskiy

J.K. Gooden

R. Ramanathan

M.L. Gross

Quadrupole Mass Filters and Quadrupole Ion Traps

R.G. Cooks

G. Chen

C. Weil

Time-of-Flight Mass Spectrometry

M.L. Vestal

Combined Analyzer Technologies

P. Kofel

U.P. Schlunegger

Fourier Transform Mass Spectrometry

M.L. Easterling

I.J. Amster

Part III: Application to Biomolecules

Protein Characterization by MS in Pharmaceutical Industry. Structural Characterization of Modified Forms of Recombinant Hirudin Sequence Variant 1 and Direct Batch Analysis

D. Muller

P. Schindler

M. Coulot

W.J. Richter

W. Maerki

H. Grossenbacher

Folding Pathways of Disulphide Containing Proteins

M. Ruoppolo

F. Talamo

P. Pucci

G. Marino

Integration of Chemical Modifications Reactions and Mass Spectrometric Methods in Protein Characterisation

S. Foti

PSD-MALDI Analysis of Peptides

B. Spengler

Development of a Mass Spectrometric Approach for the Characterisation of Hemoglobin Adducts

P. Ferranti

N. Sannolo

G. Mamone

G. Forte

A. Malorni

Reactivity of Antineoplastic Drugs with Model Peptides Studies by Advanced Mass Spectrometry Methodologies

V. Carbone

G. Pocsfalvi

N. Sannolo

A. Malorni

Applications of Mass Spectrometry in Biochemical Studies of Nucleosides, Nucleotides and Nucleic Acids

R.P. Newton

MALDI Mass Analysis of Oligonucleotides

U. Bahr

M. Karas

DNA Adducts in Human Carcinogenesis. Clues to Etiology and Mechanism

H. Bartsch

MALDIMS of Oligo and Polysaccharides

D. Garozzo

Mass Spectrometry of Isoeicosanoids as Novel Lipid Substances

R.C. Murphy

R.J. Waugh

The Role of Mass Spectrometry in the Characterization of Plant Metabolites from Crude Extracts

A. DeNino

A. Napoli

G. Sindona

Environmental Applications of Mass Spectrometry: Toxaphene Analysis

F.I. Onuska

R.J. Maguire

The Determination of Polar Compounds in the Aquatic Environment

M.J.F. Suter

Some Mass Spectrometry Contributions in the Study of Cultural Heritage

P. Agozzino

Index