Product Description: This book discusses the recent developments which will lead to the routine use of supercritical fluid in analytical extensive chemistry. Individual chapters, written by authorities in their fields, contain the maximum of practical advice in addition to covering appropriate theoretical detail...read more

Product Description: Explores both the benefits and limitations of new UHPLC technologyHigh performance liquid chromatography (HPLC) has been widely used in analytical chemistry and biochemistry to separate, identify, and quantify compounds for decades...read more

Product Description: The isolation and structural characterization of substances present at very low concentrations, as is necessary to satisfy regulatory requirements for pharmaceutical drug degradants and impurities, can present scientific challenges...read more

Product Description: A single source of authoritative information on all aspects of the practice of modern liquid chromatography suitable for advanced students and professionals working in a laboratory or managerial capacityChapters written by authoritative and visionary experts in the field provide an overview and focused treatment of a single topicComprehensive coverage of modern liquid chromatography from theory, to methods, to selected applicationsThorough selected references and tables with commonly used data to facilitate research, practical work, comparison of results, and decision makingExtensive original tables and figures, placing recent research developments into a general contextWorked examples, intuitive explanations, and clear figures reinforce learnin...read more

Product Description: A single source of authoritative information on all aspects of the practice of modern liquid chromatography suitable for advanced students and professionals working in a laboratory or managerial capacityChapters written by authoritative and visionary experts in the field provide an overview and focused treatment of a single topicEach chapter emphasizes the integration of chromatographic methods and sample preparation, automation, and explains how liquid chromatography is used in different industrial sectorsFocuses on expanding and illustrating the main features of the fundamental section, while demonstrating where and how the best practices of liquid chromatography are utilizedComprehensive coverage of modern liquid chromatography from theory, to methods, to selected applicationsThorough selected references and tables with commonly used data to facilitate research, practical work, comparison of results, and decision makin...read more

Product Description: The purpose of this book is to indicate the value of HPLC in various areas of endocrinology. Each chapter provides the reader with guidelines as to how to apply HPLC in a practical fashion based on the authors' own experience of HPLC in the separation of compounds...read more

Product Description: Liquid chromatography has proved to be one of the most important tools for separations. Rapid development in biotechnology has increased the demand for chromatography in analytical, preparative and large scale applications. The understanding of the dynamics of chromatography is imperative for the scale-up...read more

Product Description: Hands-on experts from academia and industry comprehensively describe how to successfully perform all the critical HPLC techniques needed for the analysis of peptides and proteins. The methods range from commonly used techniques to those for capillary to large-scale preparative isolation...read more

Product Description: Jump into the HPLC adventure!Three decades on from publication of the 1st German edition of Veronika Meyer's book on HPLC, this classic text remains one of the few titles available on general HPLC aimed at practitioners.New sections on the following topics have been included in this fifth edition:Comparison of HPLC with capillary electrophoresisHow to obtain peak capacityvan Deemter curves and other coherencesHydrophilic interaction chromatographyMethod transferComprehensive two-dimensional HPLCFast separations at 1000 barHPLC with superheated waterIn addition, two chapters on the instrument test and troubleshooting in the appendix have been updated and expanded by Bruno E...read more

Veronika Meyer’s book on HPLC is a classic text and remains one of the few titles available on general HPLC. Following on from the success of the previous three editions, this new, fourth edition continues to provide users of HPLC in industry, government, and service laboratories, as well as postgraduate students, with a unified approach to HPLC and an equal treatment of the theory and practice of this important technique.The contents of this edition have been revised, expanded and updated. Where available, old literature references have been replaced by recent ones. New sections on the following topics have been included: Shelf-live of mobile phasesThe mixing crossPhase systems in ion chromatographyMeasurement uncertainty

Product Description: Traditionally mycotoxins are mainly determined by immunoassay screening methods or by single compound chromatographic analytical methods, based on immunoaffinity column cleanup followed by a separation step using thin layer chromatography (TLC), gas chromatography (GC) or liquid chromatography (LC), which were coupled to conventional detectors such as electron capture detection (ECD), fluorescence or UV-visible detection...read more

Product Description: Chromatography has many roles in forensic science, ranging from toxicology to environmental analysis. In particular, high-performance liquid chromatography (HPLC) is a primary method of analysis in many types of laboratories. Maintaining a balance between practical solutions and the theoretical considerations involved in HPLC analysis, Forensic Applications of High Performance Liquid Chromatography uses real-life examples likely to be found within a forensic science laboratory to explain HPLC from a forensic perspective...read more

Product Description: Chromatography is the collective term for a set of laboratory techniques for the separation of mixtures. It involves passing a mixture dissolved in a 'mobile phase' through a stationary phase, which separates the analyte to be measured from other molecules in the mixture and allows it to be isolated...read more

The latest edition of the authoritative reference to HPLCHigh-performance liquid chromatography (HPLC) is today the leading technique for chemical analysis and related applications, with an ability to separate, analyze, and/or purify virtually any sample. Snyder and Kirkland's Introduction to Modern Liquid Chromatography has long represented the premier reference to HPLC. This Third Edition, with John Dolan as added coauthor, addresses important improvements in columns and equipment, as well as major advances in our understanding of HPLC separation, our ability to solve problems that were troublesome in the past, and the application of HPLC for new kinds of samples.This carefully considered Third Edition maintains the strengths of the previous edition while significantly modifying its organization in light of recent research and experience. The text begins by introducing the reader to HPLC, its use in relation to other modern separation techniques, and its history, then leads into such specific topics as:The basis of HPLC separation and the general effects of different experimental conditionsEquipment and detectionThe column—the "heart" of the HPLC systemReversed-phase separation, normal-phase chromatography, gradient elution, two-dimensional separation, and other techniquesComputer simulation, qualitative and quantitative analysis, and method validation and quality controlThe separation of large molecules, including both biological and synthetic polymersChiral separations, preparative separations, and sample preparationSystematic development of HPLC separations—new to this editionTroubleshooting tricks, techniques, and case studies for both equipment and chromatogramsDesigned to fulfill the needs of the full range of HPLC users, from novices to experts, Introduction to Modern Liquid Chromatography, Third Edition offers the most up-to-date, comprehensive, and accessible survey of HPLC methods and applications available.

Product Description: This book addresses recent developments in enzymes and HPLC methods, along with their use in various laboratory applications. This includes the application of HPLC and enzymes to more disciplines; advances in separation techniques and instrumentation that have increased HPLC capability; and the discovery of new enzymes and resulting new methods of analysis...read more

Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, Liquid Chromatography Time-of-Flight Mass Spectrometry shows readers how to analyze unknown and emerging contaminants—such as antibiotics, steroids, analgesics—using advanced mass spectrometry techniques. The text combines theoretical discussion with concrete examples, making it suitable for analytical chemists, environmental chemists, organic chemists, medicinal chemists, university research chemists, and graduate and post-doctorate students.

Multidimensional Liquid Chromatography (MDLC) is a very powerful separation technique for analyzing exceptionally complex samples in one step. This authoritative reference presents a number of recent contributions that help define the current art and science of MDLC. Topics covered include instrumentation, theory, methods development, and applications of MDLC in the life sciences and in industrial chemistry. With the information to help you perform very difficult separations of complex samples, this reference includes chapters contributed by leading experts or teams of experts.

The development of chiral liquid chromatography, facilitating the straightforward separation of enantiomers, was a significant advance in chromatography, leading to widespread application in analytical chemistry. Application in preparative chromatography has been less rapid, but with the development of single enantiomer pharmaceuticals its use is increasingly common in chemical synthesis at laboratory, pilot plant and even full production scale. Brings non-experts up to speed quickly and comprehensively, facilitating the rapid development of effective separations of enantiomeric mixtures on a range of process scales Presents case studies drawn from within the pharmaceutical industry to clearly illustrate the utility and value of preparative scale enantioselective chromatography in chemical research, development and production Key reference source and entry to the literature so the reader does not have to engage in expensive and time consuming literature searching

Product Description: Stability-Indicating HPLC Methods for Drug Analysis compiles summaries of stability-indicating HPLC analytical methods that have appeared in the published literature. A first stop for pharmaceutical scientists, analytical chemists, and librarians in the quest for information about the stability of drugs...read more

Product Description: This is one of the first books to focus on the dynamic aspect of proteomes. The book introduces proteomics to the newcomer, reviews the theoretical aspects of proteomics and its state-of-the art technologies, along with a number of biological applications using "classical" proteomic technology...read more

Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.

HPLC for Pharmaceutical Scientists is an excellent book for both novice and experienced pharmaceutical chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry. It provides a unified approach to HPLC with an equal and balanced treatment of the theory and practice of HPLC in the pharmaceutical industry.In-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases and columns are well blended with the practical aspects of fast and effective method development and method validation. Practical and pragmatic approaches and actual examples of effective development of selective and rugged HPLC methods from a physico-chemical point of view are provided.This book elucidates the role of HPLC throughout the entire drug development process from drug candidate inception to marketed drug product and gives detailed specifics of HPLC application in each stage of drug development.The latest advancements and trends in hyphenated and specialized HPLC techniques (LC-MS, LC-NMR, Preparative HPLC, High temperature HPLC, high pressure liquid chromatography) are also discussed.

This Second Edition of the classic handbook details how to set up an HPLC system that capitalizes on the latest innovations. It covers new techniques in high-temperature, micro-flow, and ultra-fast chromatography, the linking of an HPLC to a mass spectrometer, and more. Complete with a CD-ROM and appendices, this guide has everything chromatographers need to know to confidently separate, identify, purify, and quantify compounds.Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

Product Description: The different LC-MS techniques available today were developed to suit specific analytical needs and the application range covered by each one is wide, but still limited. GC amenable compounds can be all analyzed with a single GC-MS system whereas HPLC applications call for specific LC-MS instrumental arrangements...read more